Anti-CA2 antibody (161-260) [S8MR] (STJ11102438)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Carbonic anhydrase 2 (161-260) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S8MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CA2 |
| Gene ID | 760 |
| Uniprot ID | CAH2_HUMAN |
| Immunogen Region | 161-260 |
| Immunogen Sequence | DVLDSIKTKGKSADFTNFDP RGLLPESLDYWTYPGSLTTP PLLECVTWIVLKEPISVSSE QVLKFRKLNFNGEGEPEELM VDNWRPAQPLKNRQIKASFK |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 161-260 of human Carbonic Anhydrase 2 (CA2) (P00918). |
Additional Info
| Function | Catalyzes the reversible hydration of carbon dioxide. Can also hydrate cyanamide to urea. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. Essential for bone resorption and osteoclast differentiation. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. |
| Protein Name | Carbonic Anhydrase 2Carbonate Dehydratase IiCarbonic Anhydrase CCacCarbonic Anhydrase IiCa-IiCyanamide Hydratase Ca2 |
| Database Links | Reactome: R-HSA-1237044Reactome: R-HSA-1247673Reactome: R-HSA-1475029 |
| Cellular Localisation | CytoplasmCell MembraneColocalized With Slc26a6 At The Surface Of The Cell Membrane In Order To Form A Bicarbonate Transport MetabolonDisplaced From The Cytosolic Surface Of The Cell Membrane By Pkc In Phorbol Myristate Acetate (Pma)-Induced Cells |
| Alternative Antibody Names | Anti-Carbonic Anhydrase 2 antibodyAnti-Carbonate Dehydratase Ii antibodyAnti-Carbonic Anhydrase C antibodyAnti-Cac antibodyAnti-Carbonic Anhydrase Ii antibodyAnti-Ca-Ii antibodyAnti-Cyanamide Hydratase Ca2 antibodyAnti-CA2 antibody |
Information sourced from Uniprot.org