Anti-CA125 antibody [4601] (STJ400019)

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STJ400019
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Short Description :Mouse monoclonal anti-CA125 for use in LF and FIA in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:LF/FIA
Host:Mouse
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :4601
Isotype:IgG1
Conjugation:Unconjugated
Concentration:5.0 mg/ml (+/-10 %)
Formulation:50 mM citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
Storage Instruction:Store at 2–8 °C, and do not freeze.
Immunogen:Antibody 4601 is OC125-like and belongs to group A (ISOBM classification) as described in Nustad et al. 1996.
Specificity:Antibody recognizes human cancer antigen 125 (CA125). Does not recognize carbohydrate antigen 19-9 (CA19-9) , cancer antigen 15-3 (CA15-3) , CYFRA 21-1, carcinoembryonic antigen (CEA) , alpha fetoprotein (AFP) , or human epididymis protein 4 (HE4)
Tissue Specificity Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas.
Post Translational Modifications Heavily O-glycosylated.expresses both type 1 and type 2 core glycans. Heavily N-glycosylated.expresses primarily high mannose and complex bisecting type N-linked glycans. May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space. May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.
Function Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
Protein Name Mucin-16
Muc-16
Ovarian Cancer-Related Tumor Marker Ca125
Ca-125
Ovarian Carcinoma Antigen Ca125
Database Links Reactome: R-HSA-5083625
Reactome: R-HSA-5083632
Reactome: R-HSA-5083636
Reactome: R-HSA-5621480
Reactome: R-HSA-913709
Reactome: R-HSA-977068
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Secreted
Extracellular Space
May Be Liberated Into The Extracellular Space Following The Phosphorylation Of The Intracellular C-Terminus Which Induces The Proteolytic Cleavage And Liberation Of The Extracellular Domain
Alternative Antibody Names Anti-Mucin-16 antibody
Anti-Muc-16 antibody
Anti-Ovarian Cancer-Related Tumor Marker Ca125 antibody
Anti-Ca-125 antibody
Anti-Ovarian Carcinoma Antigen Ca125 antibody
Anti-MUC16 antibody
Anti-CA125 antibody

Information sourced from Uniprot.org

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