Anti-CA125 antibody [X325] (STJ16101901)

SKU:
STJ16101901-02

£759.50
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Host: Mouse
Applications: ELISA/IHC-P/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CA125 is suitable for use in ELISA, Immunohistochemistry and Western Blot research applications.
Clonality: Monoclonal
Clone ID: X325
Conjugation: Unconjugated
Isotype: IgG1
Formulation: PBS with <0.1% sodium azide
Purification: Purified
Concentration: 1 mg/mL
Storage Instruction: Store aliquots at-20°C, and thawed aliquots at 2-8°C.
Immunogen: CA125 antigen purified from human ovarian carcinoma
Background Mouse anti Human CA125 antibody, clone X325 recognizes the ovarian cancer mucin CA125 (also known as MUCIN 16). CA125 consists of a short cytoplasmic tail, a transmembrane domain and an exceptionally large glycosylated extracellular domain. The extracellular domain is dominated by a large number of 156-amino acid repeat units, over 60 in all. These repeats are known to bind the antibodies OC125 and M-11. CA125 is present within normal ovarian, endometrium, endocervix and fallopian tissue, but levels are elevated in over 90% of women with advanced ovarian cancer. CA125 levels may also be elevated in other cancers and non-cancerous conditions such as peritonitis, endometriosis and liver cirrhosis. Levels may also fluctuate during the menstrual cycle and occasionally increases in pregnancy, making CA125 an unreliable marker for ovarian cancer in premenopausal women. The function of CA125 in healthy tissue is unknown but it is thought to provide a protective lubricating barrier against particles and infectious agents at mucosal surfaces

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance