Anti-CA125 antibody [4601] (STJ400019)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenAntibody 4601 is OC125-like and belongs to group A (ISOBM classification) as described in Nustad et al. 1996.
General Information
| Short Description | Mouse monoclonal anti-CA125 for use in LF and FIA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | LF/FIA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 4601 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 5.0 mg/ml (+/-10 %) |
| Formulation | 50 mM citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative |
| Storage Instruction | Store at 2–8 °C, and do not freeze. |
Target Information
| Immunogen | Antibody 4601 is OC125-like and belongs to group A (ISOBM classification) as described in Nustad et al. 1996. |
| Specificity | Antibody recognizes human cancer antigen 125 (CA125). Does not recognize carbohydrate antigen 19-9 (CA19-9) , cancer antigen 15-3 (CA15-3) , CYFRA 21-1, carcinoembryonic antigen (CEA) , alpha fetoprotein (AFP) , or human epididymis protein 4 (HE4) |
Additional Info
| Tissue Specificity | Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas. |
| Post Translational Modifications | Heavily O-glycosylated.expresses both type 1 and type 2 core glycans. Heavily N-glycosylated.expresses primarily high mannose and complex bisecting type N-linked glycans. May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space. May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts. |
| Function | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. |
| Protein Name | Mucin-16Muc-16Ovarian Cancer-Related Tumor Marker Ca125Ca-125Ovarian Carcinoma Antigen Ca125 |
| Database Links | Reactome: R-HSA-5083625Reactome: R-HSA-5083632Reactome: R-HSA-5083636Reactome: R-HSA-5621480Reactome: R-HSA-913709Reactome: R-HSA-977068 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinSecretedExtracellular SpaceMay Be Liberated Into The Extracellular Space Following The Phosphorylation Of The Intracellular C-Terminus Which Induces The Proteolytic Cleavage And Liberation Of The Extracellular Domain |
| Alternative Antibody Names | Anti-Mucin-16 antibodyAnti-Muc-16 antibodyAnti-Ovarian Cancer-Related Tumor Marker Ca125 antibodyAnti-Ca-125 antibodyAnti-Ovarian Carcinoma Antigen Ca125 antibodyAnti-MUC16 antibodyAnti-CA125 antibody |
Information sourced from Uniprot.org