| Function | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N3 position of a uridine in 28S rRNA. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. Also involved in chromosome alignment. May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis. Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level. |
| Protein Name | 28s RrnaUridine-N(3-MethyltransferaseCentromere Protein 32Cenp-32Kinetochore-Associated ProteinMethyltransferase C9orf114Ribosomal Rna Methyltransferase Spout1Spout Domain-Containing Methyltransferase 1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonSpindleChromosomeCentromereKinetochoreMicrotubule Organizing CenterCentrosomeAssociated With The Outer Kinetochore |
| Alternative Antibody Names | Anti-28s Rrna antibodyAnti-Uridine-N(3-Methyltransferase antibodyAnti-Centromere Protein 32 antibodyAnti-Cenp-32 antibodyAnti-Kinetochore-Associated Protein antibodyAnti-Methyltransferase C9orf114 antibodyAnti-Ribosomal Rna Methyltransferase Spout1 antibodyAnti-Spout Domain-Containing Methyltransferase 1 antibodyAnti-SPOUT1 antibodyAnti-C9orf114 antibody |
Information sourced from Uniprot.org
