| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | C8G |
| Gene ID: | 733 |
| Uniprot ID: | CO8G_HUMAN |
| Immunogen Region: | 1-202 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-202 of human C8G (NP_000597.2). |
| Immunogen Sequence: | MLPPGTATLLTLLLAAGSLG QKPQRPRRPASPISTIQPKA NFDAQQFAGTWLLVAVGSAC RFLQEQGHRAEATTLHVAPQ GTAMAVSTFRKLDGICWQVR QLYGDTGVLGRFLLQARDAR GAVHVVVAETDYQSFAVLYL ERAGQLSVKLYARSLPVSDS VLSGFEQRVQEAHLTEDQIF YFPKYGFCEAADQFHVLDEV RR |
| Function | C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. |
| Protein Name | Complement Component C8 Gamma Chain |
| Database Links | Reactome: R-HSA-166665Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Complement Component C8 Gamma Chain antibodyAnti-C8G antibody |
Information sourced from Uniprot.org
