| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | C6 |
| Gene ID: | 729 |
| Uniprot ID: | CO6_HUMAN |
| Immunogen Region: | 586-934 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 586-934 of human C6 (NP_000056.2). |
| Immunogen Sequence: | TRECNNPAPQRGGKRCEGEK RQEEDCTFSIMENNGQPCIN DDEEMKEVDLPEIEADSGCP QPVPPENGFIRNEKQLYLVG EDVEISCLTGFETVGYQYFR CLPDGTWRQGDVECQRTECI KPVVQEVLTITPFQRLYRIG ESIELTCPKGFVVAGPSRYT CQGNSWTPPISNSLTCEKDT LTKLKGHCQLGQKQSGSECI CMSPEEDCSHHSEDLCVFDT DSNDYFTSPACKFLAEKCL |
| Post Translational Modifications | All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module. |
| Function | Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. |
| Protein Name | Complement Component C6 |
| Database Links | Reactome: R-HSA-166665Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Complement Component C6 antibodyAnti-C6 antibody |
Information sourced from Uniprot.org