| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EMSY |
| Gene ID: | 56946 |
| Uniprot ID: | EMSY_HUMAN |
| Immunogen Region: | 1153-1322 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1153-1322 of human C11orf30 (NP_064578.2). |
| Immunogen Sequence: | SLMEAQIDTNVEHMIVDPPK KALATSMLTGEAGSLPSTHM VVAGMANSTPQQQKCRESCS SPSTVGSSLTTRKIDPPAVP ATGQFMRIQNVGQKKAEESP AEIIIQAIPQYAIPCHSSSN VVVEPSGLLELNNFTSQQLD DEETAMEQDIDSSTEDGTEP SPSQSSAERS |
| Post Translational Modifications | O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status. |
| Function | Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. Mediates ligand-dependent transcriptional activation by nuclear hormone receptors. |
| Protein Name | Brca2-Interacting Transcriptional Repressor Emsy |
| Cellular Localisation | NucleusLocalizes To Dna Damage Markers In Irradiated CellsSuggesting That It Participates In Dna Repair Process |
| Alternative Antibody Names | Anti-Brca2-Interacting Transcriptional Repressor Emsy antibodyAnti-EMSY antibodyAnti-C11orf30 antibodyAnti-GL002 antibody |
Information sourced from Uniprot.org