| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BRPF1 |
| Gene ID: | 7862 |
| Uniprot ID: | BRPF1_HUMAN |
| Immunogen Region: | 1-200 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human BRPF1 (NP_001003694). |
| Immunogen Sequence: | MGVDFDVKTFCHNLRATKPP YECPVETCRKVYKSYSGIEY HLYHYDHDNPPPPQQTPLRK HKKKGRQSRPANKQSPSPSE VSQSPGREVMSYAQAQRMVE VDLHGRVHRISIFDNLDVVS EDEEAPEEAPENGSNKENTE TPAATPKSGKHKNKEKRKDS NHHHHHNVSASTTPKLPEVV YRELEQDTPDAPPRPTSYYR |
| Tissue Specificity | High levels in testis. |
| Post Translational Modifications | Acetylated by KAT6A. |
| Function | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation. Positively regulates the transcription of RUNX1 and RUNX2. |
| Protein Name | PeregrinBromodomain And Phd Finger-Containing Protein 1Protein Br140 |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-6804758 |
| Cellular Localisation | NucleusChromosomeCytoplasmLocalization To The Nucleus Depends On Kat6aIng5 And Meaf6Localizes To Transcription Start Sites |
| Alternative Antibody Names | Anti-Peregrin antibodyAnti-Bromodomain And Phd Finger-Containing Protein 1 antibodyAnti-Protein Br140 antibodyAnti-BRPF1 antibodyAnti-BR140 antibody |
Information sourced from Uniprot.org