| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4836RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BNIP3 |
| Gene ID: | 664 |
| Uniprot ID: | BNIP3_HUMAN |
| Immunogen Region: | 40-120 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-120 of human BNIP3 (NP_004043.3). |
| Immunogen Sequence: | AFPPPAAEAHPAARRGLRSP QLPSGAMSQNGAPGMQEESL QGSWVELHFSNNGNGGSVPA SVSIYNGDMEKILLDAQHES G |
| Function | Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. |
| Protein Name | Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3 |
| Cellular Localisation | Mitochondrion Mitochondrion Outer Membrane Single-Pass Membrane Protein Coexpression With The Eib 19-Kda Protein Results In A Shift In Nip3 Localization Pattern To The Nuclear Envelope Colocalizes With Acaa2 In The Mitochondria Colocalizes With Spata18 At The Mitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3 antibody Anti-BNIP3 antibody Anti-NIP3 antibody |
Information sourced from Uniprot.org