| Post Translational Modifications | Polyubiquitinated. 'Lys-63'-linked polyubiquitination by RNF185 increases the interaction with the autophagy receptor SQSTM1. Undergoes 'Lys-29'- and 'Lys-63'-linked polyubiquitination by RNF186 that may regulate BNIP1 localization to the mitochondrion. |
| Function | As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization. Also plays a role in apoptosis. It is for instance required for endoplasmic reticulum stress-induced apoptosis. As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable). |
| Protein Name | Vesicle Transport Protein Sec20Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 1Transformation-Related Gene 8 ProteinTrg-8 |
| Database Links | Reactome: R-HSA-6811434 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinMitochondrion MembraneLocalization To The Mitochondrion Is Regulated By Rnf186 |
| Alternative Antibody Names | Anti-Vesicle Transport Protein Sec20 antibodyAnti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 1 antibodyAnti-Transformation-Related Gene 8 Protein antibodyAnti-Trg-8 antibodyAnti-BNIP1 antibodyAnti-NIP1 antibodyAnti-SEC20L antibodyAnti-TRG8 antibody |
Information sourced from Uniprot.org
