| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BMPR2 (739-1038) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BMPR2 |
| Gene ID: |
659 |
| Uniprot ID: |
BMPR2_HUMAN |
| Immunogen Region: |
739-1038 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 739-1038 of human BMPR2 (NP_001195.2). |
| Immunogen Sequence: |
PTQIYPLPKQQNLPKRPTSL PLNTKNSTKEPRLKFGSKHK SNLKQVETGVAKMNTINAAE PHVVTVTMNGVAGRNHSVNS HAATTQYANGTVLSGQTTNI VTHRAQEMLQNQFIGEDTRL NINSSPDEHEPLLRREQQAG HDEGVLDRLVDRRERPLEGG RTNSNNNNSNPCSEQDVLAQ GVPSTAADPGPSKPRRAQRP NSLDLSATNVLDGSSIQIGE STQDGKSGSGEKIKKRVKT |
| Tissue Specificity | Highly expressed in heart and liver. |
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. |
| Protein Name | Bone Morphogenetic Protein Receptor Type-2Bmp Type-2 ReceptorBmpr-2Bone Morphogenetic Protein Receptor Type IiBmp Type Ii ReceptorBmpr-Ii |
| Database Links | Reactome: R-HSA-201451 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein Receptor Type-2 antibodyAnti-Bmp Type-2 Receptor antibodyAnti-Bmpr-2 antibodyAnti-Bone Morphogenetic Protein Receptor Type Ii antibodyAnti-Bmp Type Ii Receptor antibodyAnti-Bmpr-Ii antibodyAnti-BMPR2 antibodyAnti-PPH1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and BMPR2 knockout (KO) HeLa cells, using [KO Validated] BMPR2 Rabbit polyclonal antibody (STJ11100052) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89123/357574/STJ11100052_1__66941.1713121704.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and BMPR2 knockout (KO) HeLa cells, using [KO Validated] BMPR2 Rabbit polyclonal antibody (STJ11100052) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.")