• Western blot analysis of lysates from wild type (WT) and BMPR2 knockout (KO) HeLa cells, using [KO Validated] BMPR2 Rabbit polyclonal antibody (STJ11100052) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.

Anti-BMPR2 antibody (27-150) (STJ11100052)

SKU:
STJ11100052

£212.50 - £501.50
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-BMPR2 (27-150) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BMPR2
Gene ID: 659
Uniprot ID: BMPR2_HUMAN
Immunogen Region: 27-150
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 27-150 of human BMPR2 (NP_001195.2).
Immunogen Sequence: SQNQERLCAFKDPYQQDLGI GESRISHENGTILCSKGSTC YGLWEKSKGDINLVKQGCWS HIGDPQECHYEECVVTTTPP SIQNGTYRFCCCSTDLCNVN FTENFPPPDTTPLSPPHSFN RDET
Tissue Specificity Highly expressed in heart and liver.
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
Protein Name Bone Morphogenetic Protein Receptor Type-2
Bmp Type-2 Receptor
Bmpr-2
Bone Morphogenetic Protein Receptor Type Ii
Bmp Type Ii Receptor
Bmpr-Ii
Database Links Reactome: R-HSA-201451
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Bone Morphogenetic Protein Receptor Type-2 antibody
Anti-Bmp Type-2 Receptor antibody
Anti-Bmpr-2 antibody
Anti-Bone Morphogenetic Protein Receptor Type Ii antibody
Anti-Bmp Type Ii Receptor antibody
Anti-Bmpr-Ii antibody
Anti-BMPR2 antibody
Anti-PPH1 antibody

Information sourced from Uniprot.org

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