Anti-BMP2 antibody (340-396) {Biotin} (STJ506156)

SKU:
STJ506156-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-BMP2 (340-396) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:500-1:5, 000
ELISA: 1:50, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: BMP2
Gene ID: 650
Uniprot ID: BMP2_HUMAN
Immunogen Region: 340-396
Immunogen: Synthetic peptide corresponding to amino acids within region 340-396 on human Bone morphogenetic Protein 2.
Tissue Specificity Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.
Function Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3. Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation. Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling.
Protein Name Bone Morphogenetic Protein 2
Bmp-2
Bone Morphogenetic Protein 2a
Bmp-2a
Database Links Reactome: R-HSA-201451
Reactome: R-HSA-2129379
Reactome: R-HSA-8878166
Reactome: R-HSA-8939902
Cellular Localisation Secreted
Alternative Antibody Names Anti-Bone Morphogenetic Protein 2 antibody
Anti-Bmp-2 antibody
Anti-Bone Morphogenetic Protein 2a antibody
Anti-Bmp-2a antibody
Anti-BMP2 antibody
Anti-BMP2A antibody

Information sourced from Uniprot.org

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