| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Bone morphogenetic protein 10 (361-410 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:10000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BMP10 |
| Gene ID: | 27302 |
| Uniprot ID: | BMP10_HUMAN |
| Immunogen Region: | 361-410 aa |
| Specificity: | BMP-10 Polyclonal Antibody detects endogenous levels of BMP-10 |
| Immunogen: | Synthesized peptide derived from BMP-10 at the amino acid range 361-410 |
| Function | Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. |
| Protein Name | Bone Morphogenetic Protein 10Bmp-10 |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-2129379 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein 10 antibodyAnti-Bmp-10 antibodyAnti-BMP10 antibody |
Information sourced from Uniprot.org
