| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
BLOC1S1 |
| Gene ID: |
2647 |
| Uniprot ID: |
BL1S1_HUMAN |
| Immunogen Region: |
29-153 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 29-153 of human BLOC1S1 (NP_001478.2). |
| Immunogen Sequence: |
MLSRLLKEHQAKQNERKELQ EKRRREAITAATCLTEALVD HLNVGVAQAYMNQRKLDHEV KTLQVQAAQFAKQTGQWIGM VENFNQALKEIGDVENWARS IELDMRTIATALEYVYKGQL QSAPS |
| Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9. |
| Protein Name | Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 1Bloc-1 Subunit 1Gcn5-Like Protein 1Protein Rt14 |
| Database Links | Reactome: R-HSA-432720Reactome: R-HSA-432722 |
| Cellular Localisation | Mitochondrion Intermembrane SpaceMitochondrion MatrixCytoplasmCytosolLysosome Membrane |
| Alternative Antibody Names | Anti-Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 1 antibodyAnti-Bloc-1 Subunit 1 antibodyAnti-Gcn5-Like Protein 1 antibodyAnti-Protein Rt14 antibodyAnti-BLOC1S1 antibodyAnti-BLOS1 antibodyAnti-GCN5L1 antibodyAnti-RT14 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
