| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BIN1 (230-409) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200IF/ICC 1:20-1:50 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BIN1 |
| Gene ID: |
274 |
| Uniprot ID: |
BIN1_HUMAN |
| Immunogen Region: |
230-409 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 230-409 of human BIN1 (NP_647601.1). |
| Immunogen Sequence: |
QNLNDVLVGLEKQHGSNTFT VKAQPSDNAPAKGNKSPSPP DGSPAATPEIRVNHEPEPAG GATPGATLPKSPSQSSLPAV VVETFPATVNGTVEGGSGAG RLDLPPGFMFKVQAQHDYTA TDTDELQLKAGDVVLVIPFQ NPEEQDEGWLMGVKESDWNQ HKELEKCRGVFPENFTERVP |
| Tissue Specificity | Ubiquitous. Highest expression in the brain and muscle. Expressed in oligodendrocytes. Isoform IIA is expressed only in the brain, where it is detected in the gray matter, but not in the white matter. Isoform BIN1 is widely expressed with highest expression in skeletal muscle. |
| Post Translational Modifications | Phosphorylated by protein kinase C. |
| Function | Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis. Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates. May be involved in the regulation of MYC activity and the control cell proliferation. Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro. |
| Protein Name | Myc Box-Dependent-Interacting Protein 1Amphiphysin IiAmphiphysin-Like ProteinBox-Dependent Myc-Interacting Protein 1Bridging Integrator 1 |
| Database Links | Reactome: R-HSA-8856828 |
| Cellular Localisation | Isoform Bin1: NucleusCytoplasmEndosomeCell MembraneSarcolemmaT-TubuleIsoform Iia: Cytoplasm |
| Alternative Antibody Names | Anti-Myc Box-Dependent-Interacting Protein 1 antibodyAnti-Amphiphysin Ii antibodyAnti-Amphiphysin-Like Protein antibodyAnti-Box-Dependent Myc-Interacting Protein 1 antibodyAnti-Bridging Integrator 1 antibodyAnti-BIN1 antibodyAnti-AMPHL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
