| Tissue Specificity | Expressed highly in brain, moderately in small intestine, weakly in testes and only faintly in liver and skeletal muscle. Not expressed in heart, kidney, lung and spleen. |
| Post Translational Modifications | Mediates RING-dependent self-ubiquitination leading to proteasomal degradation. |
| Function | Membrane-bound E3 ubiquitin ligase that plays a role in several processes including apoptosis regulation or reticulum endoplasmic stress. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors. Contributes to the dynamic control of IRE1/ERN1 signaling during ER stress by inducing BAX inhibitor 1/TMBIM6 proteasomal degradation. Promotes the activation of TGF-beta signaling by mediating the 'Lys-63'-linked ubiquitination of TGFBR1 which is critical to activate the pathway. Together with NGFR, negatively regulates NF-kappa-B and JNK-related signaling pathways. Promotes the proteasome-mediated degradation of PNPLA3, a protein involveld in lipid metabolism. |
| Protein Name | Bifunctional Apoptosis RegulatorRing Finger Protein 47 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Bifunctional Apoptosis Regulator antibodyAnti-Ring Finger Protein 47 antibodyAnti-BFAR antibodyAnti-BAR antibodyAnti-RNF47 antibody |
Information sourced from Uniprot.org
