| Short Description : | Mouse monoclonal anti-Beta-synuclein (C-Term) for use in IHC-F and WB in Bovine, Human, Mouse, Pig and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC-F/WB |
| Host: | Mouse |
| Reactivity: | Bovine/Human/Mouse/Pig/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | 6A10 |
| Isotype: | IgG1 |
| Conjugation: | Unconjugated |
| Purification: | Affinity-purified |
| Dilution Range: | WB 0.73611111111111116IHC 1:500-1:1000 |
| Formulation: | Lyophilized from PBS buffer pH 7.2-7.6 with 0.1% trehalose, and sodium azide |
| Storage Instruction: | Spin vial briefly before opening. Reconstitute with 100 µL sterile-filtered, ultrapure water to achieve a 1 mg/mL concentration. Centrifuge to remove any insoluble material. Store lyophilized antibody at 2-8°C. After reconstitution divide into aliquo |
| Gene Symbol: | SNCB |
| Gene ID: | 6620 |
| Uniprot ID: | SYUB_HUMAN |
| Immunogen: | C-terminal peptide of human Beta-synuclein (EPEGESYEDPPQEEYQEYEPEA) coupled to KLH. |
| Immunogen Region: | C-Term |
| Immunogen Sequence: | Human |
| Specificity: | Validated by Western blotting and immunohistochemical procedures. Specific for Beta-synuclein, does not cross-react with Alpha-or Gamma-synuclein. |
| Tissue Specificity | Expressed predominantly in brain.concentrated in presynaptic nerve terminals. |
| Post Translational Modifications | Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II. |
| Function | Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. |
| Protein Name | Beta-Synuclein |
| Database Links | Reactome: R-HSA-5660489 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Beta-Synuclein antibodyAnti-SNCB antibody |
Information sourced from Uniprot.org