| Host: | Rabbit |
| Applications: | CM/ELISA/IF/IHC/IP/WB |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-BEST3 (C-Term) is suitable for use in Confocal Microscopy, ELISA, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.5 µg/µl |
| Dilution Range: | WB: 1:500-1:1, 000DB: 1:10, 000ELISA: 1:10, 000IP: 1:200IHC: 1:200ICC: 1:200IF: 1:200CFM: 1:200 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | Best3 |
| Gene ID: | 382427 |
| Uniprot ID: | BEST3_MOUSE |
| Immunogen Region: | C-Term |
| Immunogen: | Synthetic peptide taken within the last 50 amino acids from the C-terminus of rat Bestrophin-3 protein. |
| Tissue Specificity | Isoform 1: Expressed in heart. Isoform 2: Expressed in brain, retina/retinal pigment epithelium (RPE) and skeletal muscle. Expressed in acinar cells of parotid glands. Expressed in lung, kidney and testis. |
| Function | Isoform 1: Ligand-gated anion channel that allows the movement of chloride monoatomic anions across cell membranes when activated by calcium (Ca2+). Isoform 2: Does not function as calcium-gated chloride channel. |
| Protein Name | Bestrophin-3Vitelliform Macular Dystrophy 2-Like Protein 3 |
| Database Links | Reactome: R-MMU-2672351 |
| Cellular Localisation | Isoform 1: Cell MembraneLocalized Also In Punctate Structures In The Cytosolic CompartmentIsoform 2: Cell Membrane |
| Alternative Antibody Names | Anti-Bestrophin-3 antibodyAnti-Vitelliform Macular Dystrophy 2-Like Protein 3 antibodyAnti-Best3 antibodyAnti-Vmd2l3 antibody |
Information sourced from Uniprot.org