| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Bcl-W (1-193) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BCL2L2 |
| Gene ID: |
599 |
| Uniprot ID: |
B2CL2_HUMAN |
| Immunogen Region: |
1-193 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-193 of human Bcl-W (NP_004041.2). |
| Immunogen Sequence: |
MATPASAPDTRALVADFVGY KLRQKGYVCGAGPGEGPAAD PLHQAMRAAGDEFETRFRRT FSDLAAQLHVTPGSAQQRFT QVSDELFQGGPNWGRLVAFF VFGAALCAESVNKEMEPLVG QVQEWMVAYLETQLADWIHS SGGWAEFTALYGDGALEEAR RLREGNWASVRTVLTGAVAL GALVTVGAFFASK |
| Tissue Specificity | Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines. |
| Function | Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. |
| Protein Name | Bcl-2-Like Protein 2Bcl2-L-2Apoptosis Regulator Bcl-W |
| Cellular Localisation | Mitochondrion MembranePeripheral Membrane ProteinLoosely Associated With The Mitochondrial Membrane In Healthy CellsDuring ApoptosisTightly Bound To The Membrane |
| Alternative Antibody Names | Anti-Bcl-2-Like Protein 2 antibodyAnti-Bcl2-L-2 antibodyAnti-Apoptosis Regulator Bcl-W antibodyAnti-BCL2L2 antibodyAnti-BCLW antibodyAnti-KIAA0271 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
