| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BCHE (29-270) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BCHE |
| Gene ID: |
590 |
| Uniprot ID: |
CHLE_HUMAN |
| Immunogen Region: |
29-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 29-270 of human Butyrylcholinesterase (NP_000046.1). |
| Immunogen Sequence: |
EDDIIIATKNGKVRGMNLTV FGGTVTAFLGIPYAQPPLGR LRFKKPQSLTKWSDIWNATK YANSCCQNIDQSFPGFHGSE MWNPNTDLSEDCLYLNVWIP APKPKNATVLIWIYGGGFQT GTSSLHVYDGKFLARVERVI VVSMNYRVGALGFLALPGNP EAPGNMGLFDQQLALQWVQK NIAAFGGNPKSVTLFGESAG AASVSLHLLSPGSHSLFTRA ILQSGSFNAPWAVTSLYEA |
| Tissue Specificity | Detected in blood plasma (at protein level). Present in most cells except erythrocytes. |
| Post Translational Modifications | N-glycosylated. No other PTM detected. The major N-glycan structures are of the complex diantennary type with 1 and 2 N-acetylneuraminic acid molecules (Neu5Ac) making up approximately 33% and 47% of the total N-glycans, respectively. Only low amounts of fucosylated diantennary N-glycans are detected (approximately 2%). Triantennary N-glycans with or without fucose amount to approximately 13%, whereas 5% of the total N-glycans are of the oligomannosidic or hybrid type. |
| Function | Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. |
| Protein Name | CholinesteraseAcylcholine AcylhydrolaseButyrylcholine EsteraseCholine Esterase IiPseudocholinesterase |
| Database Links | Reactome: R-HSA-112311Reactome: R-HSA-1483191Reactome: R-HSA-422085Reactome: R-HSA-9749641 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Cholinesterase antibodyAnti-Acylcholine Acylhydrolase antibodyAnti-Butyrylcholine Esterase antibodyAnti-Choline Esterase Ii antibodyAnti-Pseudocholinesterase antibodyAnti-BCHE antibodyAnti-CHE1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
