| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:100-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BCCIP |
| Gene ID: | 56647 |
| Uniprot ID: | BCCIP_HUMAN |
| Immunogen Region: | 1-314 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-314 of human BCCIP (NP_510868.1). |
| Immunogen Sequence: | MASRSKRRAVESGVPQPPDP PVQRDEEEEKEVENEDEDDD DSDKEKDEEDEVIDEEVNIE FEAYSLSDNDYDGIKKLLQQ LFLKAPVNTAELTDLLIQQN HIGSVIKQTDVSEDSNDDMD EDEVFGFISLLNLTERKGTQ CVEQIQELVLRFCEKNCEKS MVEQLDKFLNDTTKPVGLLL SERFINVPPQIALPMYQQLQ KELAGAHRTNKPCGKCYFYL LISKTFVEAGKNNSKKKPS |
| Tissue Specificity | Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen. |
| Function | During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ). |
| Protein Name | Brca2 And Cdkn1a-Interacting Protein P21- And Cdk-Associated Protein 1 Protein Tok-1 |
| Cellular Localisation | Nucleus Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Centriole Spindle Pole Colocalizes With Brca2 In Discrete Nuclear Foci In Interphase Preferential Localizes To The Mother Centriole Recruited To The Spindle Pole Matrix And Centrosome By Microtubules And Dynein/Dynactin Activity Isoform 1: Cytoplasm Isoform 1/Beta Tends To Be Less Abundant At And Less Strongly Associated With Centrosomes Than Isoform 2/Alpha Isoform 2: Cytoplasm Isoform 2/Alpha Tends To Be More Abundant At And More Strongly Associated With Centrosomes Than Isoform 1/Beta |
| Alternative Antibody Names | Anti-Brca2 And Cdkn1a-Interacting Protein antibody Anti-P21- And Cdk-Associated Protein 1 antibody Anti-Protein Tok-1 antibody Anti-BCCIP antibody Anti-TOK1 antibody |
Information sourced from Uniprot.org