| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Basal cell adhesion molecule (191-240 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BCAM |
| Gene ID: |
4059 |
| Uniprot ID: |
BCAM_HUMAN |
| Immunogen Region: |
191-240 aa |
| Specificity: |
CD239 Polyclonal Antibody detects endogenous levels of CD239 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the Internal region of human BCAM at the amino acid range 191-240 |
| Post Translational Modifications | Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin. Ser-621 can also be phosphorylated by AKT1. |
| Function | Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion. Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction. Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion. Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR. |
| Protein Name | Basal Cell Adhesion MoleculeAuberger B AntigenB-Cam Cell Surface GlycoproteinF8/G253 AntigenLutheran AntigenLutheran Blood Group GlycoproteinCd Antigen Cd239 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Basal Cell Adhesion Molecule antibodyAnti-Auberger B Antigen antibodyAnti-B-Cam Cell Surface Glycoprotein antibodyAnti-F8/G253 Antigen antibodyAnti-Lutheran Antigen antibodyAnti-Lutheran Blood Group Glycoprotein antibodyAnti-Cd Antigen Cd239 antibodyAnti-BCAM antibodyAnti-LU antibodyAnti-MSK19 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
