| Tissue Specificity | Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta. |
| Post Translational Modifications | Phosphorylated on tyrosine residues by INSR in response to insulin treatment. |
| Function | Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. |
| Protein Name | Bar/Imd Domain-Containing Adapter Protein 2Brain-Specific Angiogenesis Inhibitor 1-Associated Protein 2Bai-Associated Protein 2Bai1-Associated Protein 2Protein Bap2Fas Ligand-Associated Factor 3Flaf3Insulin Receptor Substrate P53/P58Irs-58Irsp53/58Insulin Receptor Substrate Protein Of 53 KdaIrsp53Insulin Receptor Substrate P53 |
| Database Links | Reactome: R-HSA-2029482Reactome: R-HSA-4420097Reactome: R-HSA-5663213Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013423Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinCell ProjectionFilopodiumRuffleCytoskeletonDetected Throughout The Cytoplasm In The Absence Of Specific Binding PartnersDetected In Filopodia And Close To Membrane RufflesRecruited To Actin Pedestals That Are Formed Upon Infection By Bacteria At Bacterial Attachment Sites |
| Alternative Antibody Names | Anti-Bar/Imd Domain-Containing Adapter Protein 2 antibodyAnti-Brain-Specific Angiogenesis Inhibitor 1-Associated Protein 2 antibodyAnti-Bai-Associated Protein 2 antibodyAnti-Bai1-Associated Protein 2 antibodyAnti-Protein Bap2 antibodyAnti-Fas Ligand-Associated Factor 3 antibodyAnti-Flaf3 antibodyAnti-Insulin Receptor Substrate P53/P58 antibodyAnti-Irs-58 antibodyAnti-Irsp53/58 antibodyAnti-Insulin Receptor Substrate Protein Of 53 Kda antibodyAnti-Irsp53 antibodyAnti-Insulin Receptor Substrate P53 antibodyAnti-BAIAP2 antibody |
Information sourced from Uniprot.org
