| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BAIAP2 (362-521) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BAIAP2 |
| Gene ID: |
10458 |
| Uniprot ID: |
BAIP2_HUMAN |
| Immunogen Region: |
362-521 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 362-521 of human BAIAP2 (NP_059344.1). |
| Immunogen Sequence: |
PRSSSMAAGLERNGRMRVKA IFSHAAGDNSTLLSFKEGDL ITLLVPEARDGWHYGESEKT KMRGWFPFSYTRVLDSDGSD RLHMSLQQGKSSSTGNLLDK DDLAIPPPDYGAASRAFPAQ TASGFKQRPYSVAVPAFSQG LDDYGARSMSSGSGTLVSTV |
| Tissue Specificity | Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta. |
| Post Translational Modifications | Phosphorylated on tyrosine residues by INSR in response to insulin treatment. |
| Function | Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. |
| Protein Name | Brain-Specific Angiogenesis Inhibitor 1-Associated Protein 2Bai-Associated Protein 2Bai1-Associated Protein 2Protein Bap2Fas Ligand-Associated Factor 3Flaf3Insulin Receptor Substrate P53/P58Irs-58Irsp53/58Insulin Receptor Substrate Protein Of 53 KdaIrsp53Insulin Receptor Substrate P53 |
| Database Links | Reactome: R-HSA-2029482Reactome: R-HSA-4420097Reactome: R-HSA-5663213Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013423Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinCell ProjectionFilopodiumRuffleCytoskeletonDetected Throughout The Cytoplasm In The Absence Of Specific Binding PartnersDetected In Filopodia And Close To Membrane RufflesRecruited To Actin Pedestals That Are Formed Upon Infection By Bacteria At Bacterial Attachment Sites |
| Alternative Antibody Names | Anti-Brain-Specific Angiogenesis Inhibitor 1-Associated Protein 2 antibodyAnti-Bai-Associated Protein 2 antibodyAnti-Bai1-Associated Protein 2 antibodyAnti-Protein Bap2 antibodyAnti-Fas Ligand-Associated Factor 3 antibodyAnti-Flaf3 antibodyAnti-Insulin Receptor Substrate P53/P58 antibodyAnti-Irs-58 antibodyAnti-Irsp53/58 antibodyAnti-Insulin Receptor Substrate Protein Of 53 Kda antibodyAnti-Irsp53 antibodyAnti-Insulin Receptor Substrate P53 antibodyAnti-BAIAP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
