| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
B4GAT1 |
| Gene ID: |
11041 |
| Uniprot ID: |
B4GA1_HUMAN |
| Immunogen Region: |
35-180 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 35-180 of human B4GAT1 (NP_006867.1). |
| Immunogen Sequence: |
GLHGQEEQDQYFEFFPPSPR SVDQVKAQLRTALASGGVLD ASGDYRVYRGLLKTTMDPND VILATHASVDNLLHLSGLLE RWEGPLSVSVFAATKEEAQL ATVLAYALSSHCPDMRARVA MHLVCPSRYEAAVPDPREPG EFALLR |
| Tissue Specificity | In the adult, highly expressed in heart, brain, skeletal muscle and kidney and to a lesser extent in placenta, pancreas, spleen, prostate, testis, ovary, small intestine and colon. Very weak expression in lung, liver, thymus and peripheral blood leukocytes. In fetal highly expressed in brain and kidney and to a lesser extent in lung and liver. |
| Function | Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan. Phosphorylated O-mannosyl glycan is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Required for axon guidance.via its function in O-mannosylation of alpha-dystroglycan (DAG1). |
| Protein Name | Beta-1 -4-Glucuronyltransferase 1I-Beta-1 -3-N-AcetylglucosaminyltransferaseIgntN-Acetyllactosaminide Beta-1 -3-N-AcetylglucosaminyltransferasePoly-N-Acetyllactosamine Extension EnzymeUdp-Glcnac -Betagal Beta-1 -3-N-Acetylglucosaminyltransferase 1 |
| Database Links | Reactome: R-HSA-2022854Reactome: R-HSA-5083627Reactome: R-HSA-5173105 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinLocalizes Near The Trans-Golgi Apparatus |
| Alternative Antibody Names | Anti-Beta-1 -4-Glucuronyltransferase 1 antibodyAnti-I-Beta-1 -3-N-Acetylglucosaminyltransferase antibodyAnti-Ignt antibodyAnti-N-Acetyllactosaminide Beta-1 -3-N-Acetylglucosaminyltransferase antibodyAnti-Poly-N-Acetyllactosamine Extension Enzyme antibodyAnti-Udp-Glcnac -Betagal Beta-1 -3-N-Acetylglucosaminyltransferase 1 antibodyAnti-B4GAT1 antibodyAnti-B3GNT1 antibodyAnti-B3GNT6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
