| Function | Beta-1,4 N-acetylgalactosaminyltransferase involved in the biosynthesis of Sd(a) histo-blood group antigen. Catalyzes the transfer of N-acetylgalactosamine (GalNAc) group in a beta-1,4-linkage from UDP-GalNAc to the galactose residue of NeuAcalpha2->3Gal-R to form Sd(a) glycan epitope GalNAcbeta1->4(NeuAcalpha2->3)Gal-R. The Sd(a) epitope is carried in O- and N-linked glycoproteins and glycolipids, including O-linked core 1 structures on GYPA/glycophorin, SLC4A1 and SLC29A1 in erythrocytes, N-linked glycans attached to the Tamm-Horsfall glycoprotein UMOD/uromodulin in renal fluids, O-linked core 3 glycans on mucins in colon and neolactosides in gastric mucosa. Confers protection against influenza A virus strains that attach to NeuAcalpha2->3-carrying host receptors. Modifies N-glycan chains on host receptors and prevents virus entry into cells. |
| Protein Name | Beta-1 -4 N-Acetylgalactosaminyltransferase 2Sd(A Beta-1 -4-Galnac TransferaseUdp-Galnac -Neu5aca2-3galb-R B1 -4-N-Acetylgalactosaminyltransferase |
| Database Links | Reactome: R-HSA-446203Reactome: R-HSA-9037629 |
| Cellular Localisation | Isoform 1: Golgi ApparatusTrans-Golgi Network MembraneSingle-Pass Type Ii Membrane ProteinCytoplasmic Vesicle MembranePartially Colocalizes With Eea1 And Lamp2 In Early Endosomes And LysosomesRespectivelyIsoform 2: Golgi Apparatus |
| Alternative Antibody Names | Anti-Beta-1 -4 N-Acetylgalactosaminyltransferase 2 antibodyAnti-Sd(A Beta-1 -4-Galnac Transferase antibodyAnti-Udp-Galnac -Neu5aca2-3galb-R B1 -4-N-Acetylgalactosaminyltransferase antibodyAnti-B4GALNT2 antibodyAnti-GALGT2 antibody |
Information sourced from Uniprot.org
