| Tissue Specificity | Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase. |
| Function | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. |
| Protein Name | Aurora Kinase CAurora 3Aurora/Ipl1-Related Kinase 3Ark-3Aurora-Related Kinase 3Aurora/Ipl1/Eg2 Protein 2Serine/Threonine-Protein Kinase 13Serine/Threonine-Protein Kinase Aurora-C |
| Cellular Localisation | NucleusChromosomeCentromereCytoplasmCytoskeletonSpindleDistributes In The Condensed Chromosomes During Prophase To MetaphaseAfter Entering AnaphaseThere Is A Dissociation From Separated Chromosomes And A Redistribution To Midzone MicrotubulesAnd Finally Remains In The Midbody During Cytokinesis |
| Alternative Antibody Names | Anti-Aurora Kinase C antibodyAnti-Aurora 3 antibodyAnti-Aurora/Ipl1-Related Kinase 3 antibodyAnti-Ark-3 antibodyAnti-Aurora-Related Kinase 3 antibodyAnti-Aurora/Ipl1/Eg2 Protein 2 antibodyAnti-Serine/Threonine-Protein Kinase 13 antibodyAnti-Serine/Threonine-Protein Kinase Aurora-C antibodyAnti-AURKC antibodyAnti-AIE2 antibodyAnti-AIK3 antibodyAnti-AIRK3 antibodyAnti-ARK3 antibodyAnti-STK13 antibody |
Information sourced from Uniprot.org
