Anti-ATXN10 antibody (10-90 aa) (STJ190567)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 10-90
General Information
| Short Description | Rabbit polyclonal anti-Ataxin-10 (10-90 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ATXN10 |
| Gene ID | 25814 |
| Uniprot ID | ATX10_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 10-90 |
| Immunogen Region | 10-90 aa |
| Specificity | ATX10 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Polyubiquitinated. Phosphorylation at Ser-12 by AURKB promotes the association of ATXN10 with PLK1. Phosphorylation at Ser-77 and Thr-82 by PLK1 may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10. |
| Function | May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons. Does not appear to play a major role in ciliogenesis. |
| Protein Name | Ataxin-10Brain Protein E46 HomologSpinocerebellar Ataxia Type 10 Protein |
| Database Links | |
| Cellular Localisation | CytoplasmPerinuclear RegionMidbodyCytoskeletonCilium Basal BodyMicrotubule Organizing CenterCentrosomeCentrioleLocalizes To The Midbody During Telophase |
| Alternative Antibody Names | Anti-Ataxin-10 antibodyAnti-Brain Protein E46 Homolog antibodyAnti-Spinocerebellar Ataxia Type 10 Protein antibodyAnti-ATXN10 antibodyAnti-SCA10 antibody |
Information sourced from Uniprot.org