| Post Translational Modifications | Polyubiquitinated. Phosphorylation at Ser-12 by AURKB promotes the association of ATXN10 with PLK1. Phosphorylation at Ser-77 and Thr-82 by PLK1 may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10. |
| Function | May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons. Does not appear to play a major role in ciliogenesis. |
| Protein Name | Ataxin-10Brain Protein E46 HomologSpinocerebellar Ataxia Type 10 Protein |
| Cellular Localisation | CytoplasmPerinuclear RegionMidbodyCytoskeletonCilium Basal BodyMicrotubule Organizing CenterCentrosomeCentrioleLocalizes To The Midbody During Telophase |
| Alternative Antibody Names | Anti-Ataxin-10 antibodyAnti-Brain Protein E46 Homolog antibodyAnti-Spinocerebellar Ataxia Type 10 Protein antibodyAnti-ATXN10 antibodyAnti-SCA10 antibody |
Information sourced from Uniprot.org
