• Western blot analysis of Ataxin 1 in 3T3 lysates using Ataxin 1 antibody.

Anti-ATXN1 antibody (562-693 aa) [R01-8H1] (STJA0010993)

SKU:
STJA0010993-100

Shipping:
Free Shipping
Current Stock:
Host: Rabbit
Applications: WB/IP
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Ataxin 1 (562-693 aa) is suitable for use in Western Blot and Immunoprecipitation research applications.
Clonality: Monoclonal
Clone ID: R01-8H1
Conjugation: Unconjugated
Isotype: IgG
Formulation: 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Purification: Affinity Purified
Concentration: 0.3 mg/ml
Dilution Range: WB 1:500-1:1000
IP 1:20
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: ATXN1
Gene ID: 6310
Uniprot ID: ATX1_HUMAN
Immunogen Region: 562-693 aa
Immunogen: Recombinant protein of human Ataxin 1
Tissue Specificity Widely expressed throughout the body.
Post Translational Modifications Ubiquitinated by UBE3A, leading to its degradation by the proteasome. The presence of expanded poly-Gln repeats in spinocerebellar ataxia 1 (SCA1) patients impairs ubiquitination and degradation, leading to accumulation of ATXN1 in neurons and subsequent toxicity. Phosphorylation at Ser-775 increases the pathogenicity of proteins with an expanded polyglutamine tract. Sumoylation is dependent on nuclear localization and phosphorylation at Ser-775. It is reduced in the presence of an expanded polyglutamine tract.
Function Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved in brain development.
Protein Name Ataxin-1
Spinocerebellar Ataxia Type 1 Protein
Cellular Localisation Cytoplasm
Nucleus
Colocalizes With Usp7 In The Nucleus
Alternative Antibody Names Anti-Ataxin-1 antibody
Anti-Spinocerebellar Ataxia Type 1 Protein antibody
Anti-ATXN1 antibody
Anti-ATX1 antibody
Anti-SCA1 antibody

Information sourced from Uniprot.org