| Host: | Goat |
| Applications: | Pep-ELISA/WB/FC |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-ATP6IP2/Renin receptor (C-Term) is suitable for use in ELISA, Western Blot and Flow Cytometry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:8000. WB: Approx 38-39kDa band observed in Human Cerebellum and in Human and Rat Heart lysates (calculated MW of 39.0kDa according to Human NP_005756.2 and Rat NP_001007092.1). Recommended concen |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | ATP6AP2 |
| Gene ID: | 10159 |
| Uniprot ID: | RENR_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_005756.2 |
| Immunogen Sequence: | SIIYRMTNQKIRMD |
| Post Translational Modifications | Phosphorylated. Proteolytically cleaved by a furin-like convertase in the trans-Golgi network to generate N- and C-terminal fragments. |
| Function | Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission. |
| Protein Name | Renin Receptor Atpase H(+-Transporting Lysosomal Accessory Protein 2 Atpase H(+-Transporting Lysosomal-Interacting Protein 2 Er-Localized Type I Transmembrane Adapter Embryonic Liver Differentiation Factor 10 N14f Renin/Prorenin Receptor Vacuolar Atp Synthase Membrane Sector-Associated Protein M8-9 Atp6m8-9 V-Atpase M8.9 Subunit Cleaved Into - Renin Receptor N-Terminal Fragment - Renin Receptor C-Terminal Fragment |
| Database Links | Reactome: R-HSA-2022377 Reactome: R-HSA-6798695 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Single-Pass Type I Membrane Protein Lysosome Membrane Cytoplasmic Vesicle Autophagosome Membrane Cell Projection Dendritic Spine Membrane Axon Endosome Membrane Clathrin-Coated Vesicle Membrane Secretory Vesicle Synaptic Vesicle Membrane |
| Alternative Antibody Names | Anti-Renin Receptor antibody Anti-Atpase H(+-Transporting Lysosomal Accessory Protein 2 antibody Anti-Atpase H(+-Transporting Lysosomal-Interacting Protein 2 antibody Anti-Er-Localized Type I Transmembrane Adapter antibody Anti-Embryonic Liver Differentiation Factor 10 antibody Anti-N14f antibody Anti-Renin/Prorenin Receptor antibody Anti-Vacuolar Atp Synthase Membrane Sector-Associated Protein M8-9 antibody Anti-Atp6m8-9 antibody Anti-V-Atpase M8.9 Subunit Cleaved Into - Renin Receptor N-Terminal Fragment - Renin Receptor C-Terminal Fragment antibody Anti-ATP6AP2 antibody Anti-ATP6IP2 antibody Anti-CAPER antibody Anti-ELDF10 antibody Anti-HT028 antibody Anti-MSTP009 antibody Anti-PSEC0072 antibody |
Information sourced from Uniprot.org