| Post Translational Modifications | N-glycosylation is necessary for assembly and functional expression of the pump at the plasma membrane. |
| Function | The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump. Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle. |
| Protein Name | Potassium-Transporting Atpase Subunit BetaGastric H(+/K(+ Atpase Subunit BetaProton Pump Beta Chain |
| Database Links | Reactome: R-HSA-936837 |
| Cellular Localisation | Apical Cell MembraneSingle-Pass Type Ii Membrane ProteinCell MembraneLocalized In The Apical Canalicular Membrane Of Parietal Cells |
| Alternative Antibody Names | Anti-Potassium-Transporting Atpase Subunit Beta antibodyAnti-Gastric H(+/K(+ Atpase Subunit Beta antibodyAnti-Proton Pump Beta Chain antibodyAnti-ATP4B antibody |
Information sourced from Uniprot.org
