| Tissue Specificity | Found in most tissues. |
| Post Translational Modifications | Glutathionylated. N-glycosylated. |
| Function | This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1. Involved in cell adhesion and establishing epithelial cell polarity. |
| Protein Name | Sodium/Potassium-Transporting Atpase Subunit Beta-1Sodium/Potassium-Dependent Atpase Subunit Beta-1 |
| Database Links | Reactome: R-HSA-210991Reactome: R-HSA-5578775Reactome: R-HSA-936837Reactome: R-HSA-9679191 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinApical Cell MembraneSarcolemmaColocalizes With Obscn At The Intercalated Disk And Sarcolemma In CardiomyocytesLocalizes In Long Striations At The Level Of Z And M Lines |
| Alternative Antibody Names | Anti-Sodium/Potassium-Transporting Atpase Subunit Beta-1 antibodyAnti-Sodium/Potassium-Dependent Atpase Subunit Beta-1 antibodyAnti-ATP1B1 antibodyAnti-ATP1B antibody |
Information sourced from Uniprot.org
