| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ATOH8 (150-250) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ATOH8 |
| Gene ID: |
84913 |
| Uniprot ID: |
ATOH8_HUMAN |
| Immunogen Region: |
150-250 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human ATOH8 (NP_116216.2). |
| Immunogen Sequence: |
LRPRILLCAPPARPAPSAPP APPAPPESTVRPAPPTRPGE SSYSSISHVIYNNHQDSSAS PRKRPGEATAASSEIKALQQ TRRLLANARERTRVHTISAA F |
| Tissue Specificity | Expressed in lung, liver, kidney, heart and pancreas. Expressed in endothel of umbilical vessels. |
| Function | Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins. Regulates endothelial cell proliferation, migration and tube-like structures formation. Modulates endothelial cell differentiation through NOS3. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation. During early embryonic development is involved in tissue-specific differentiation processes that are dependent on class II bHLH factors and namely modulates the differentiation program initiated by the pro-endocrine factor NEUROG3. During myogenesis, may play a role during the transition of myoblasts from the proliferative phase to the differentiation phase. Positively regulates HAMP transcription in two ways, firstly by acting directly on the HAMP promoter via E-boxes binding and indirectly through increased phosphorylation of SMAD protein complex. Repress NEUROG3-dependent gene activation in a gene-specific manner through at least two mechanisms.requires only either the sequestering of a general partner such as TCF3 through heterodimerization, either also requires binding of the bHLH domain to DNA via a basic motif. |
| Protein Name | Transcription Factor Atoh8Class A Basic Helix-Loop-Helix Protein 21Bhlha21Helix-Loop-Helix Protein Hath-6Hath6Protein Atonal Homolog 8 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasm |
| Alternative Antibody Names | Anti-Transcription Factor Atoh8 antibodyAnti-Class A Basic Helix-Loop-Helix Protein 21 antibodyAnti-Bhlha21 antibodyAnti-Helix-Loop-Helix Protein Hath-6 antibodyAnti-Hath6 antibodyAnti-Protein Atonal Homolog 8 antibodyAnti-ATOH8 antibodyAnti-ATH6 antibodyAnti-BHLHA21 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
