| Function | Transcription factor that binds to DNA at the consensus sequence 5'-CAGGCTG-3'. Dimerization with TCF3 isoform E47 may be required in certain situations. Binds to gene promoters and enhancer elements, and thereby regulates a transcriptional program of retinal ganglion cell (RGC) determinant genes. Although the exact mechanism is not certain, retinal transcription regulation by ATOH7 has a role in RGC determination and survival, photoreceptor population development, targeting of RGC axons to the optic nerve and development of the retino-hypothalamic tract. Binds to its own promoter and enhancer sequences, suggesting autoregulation of ATOH7 transcription. Required for retinal circadian rhythm photoentrainment. Plays a role in brainstem auditory signaling and binaural processing. |
| Protein Name | Transcription Factor Atoh7Atonal Bhlh Transcription Factor 7Class A Basic Helix-Loop-Helix Protein 13Bhlha13Protein Atonal Homolog 7 |
| Cellular Localisation | NucleusPerikaryonCell ProjectionAxon |
| Alternative Antibody Names | Anti-Transcription Factor Atoh7 antibodyAnti-Atonal Bhlh Transcription Factor 7 antibodyAnti-Class A Basic Helix-Loop-Helix Protein 13 antibodyAnti-Bhlha13 antibodyAnti-Protein Atonal Homolog 7 antibodyAnti-ATOH7 antibodyAnti-ATH5 antibodyAnti-BHLHA13 antibody |
Information sourced from Uniprot.org
