| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ATOH7 (47-152) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ATOH7 |
| Gene ID: |
220202 |
| Uniprot ID: |
ATOH7_HUMAN |
| Immunogen Region: |
47-152 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 47-152 of human ATOH7 (NP_660161.1). |
| Immunogen Sequence: |
ARERRRMQGLNTAFDRLRRV VPQWGQDKKLSKYETLQMAL SYIMALTRILAEAERFGSER DWVGLHCEHFGRDHYLPFPG AKLPGESELYSQRLFGFQPE PFQMAT |
| Function | Transcription factor that binds to DNA at the consensus sequence 5'-CAGGCTG-3'. Dimerization with TCF3 isoform E47 may be required in certain situations. Binds to gene promoters and enhancer elements, and thereby regulates a transcriptional program of retinal ganglion cell (RGC) determinant genes. Although the exact mechanism is not certain, retinal transcription regulation by ATOH7 has a role in RGC determination and survival, photoreceptor population development, targeting of RGC axons to the optic nerve and development of the retino-hypothalamic tract. Binds to its own promoter and enhancer sequences, suggesting autoregulation of ATOH7 transcription. Required for retinal circadian rhythm photoentrainment. Plays a role in brainstem auditory signaling and binaural processing. |
| Protein Name | Transcription Factor Atoh7Atonal Bhlh Transcription Factor 7Class A Basic Helix-Loop-Helix Protein 13Bhlha13Protein Atonal Homolog 7 |
| Cellular Localisation | NucleusPerikaryonCell ProjectionAxon |
| Alternative Antibody Names | Anti-Transcription Factor Atoh7 antibodyAnti-Atonal Bhlh Transcription Factor 7 antibodyAnti-Class A Basic Helix-Loop-Helix Protein 13 antibodyAnti-Bhlha13 antibodyAnti-Protein Atonal Homolog 7 antibodyAnti-ATOH7 antibodyAnti-ATH5 antibodyAnti-BHLHA13 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
