| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ATMIN |
| Gene ID: | 23300 |
| Uniprot ID: | ATMIN_HUMAN |
| Immunogen Region: | 160-360 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-360 of human ATMIN (NP_056066.2). |
| Immunogen Sequence: | HAEKKHKCSKCSNSYGTEWD LKRHAEDCGKTFRCTCGCPY ASRTALQSHIYRTGHEIPAE HRDPPSKKRKMENCAQNQKL SNKTIESLNNQPIPRPDTQE LEASEIKLEPSFEDSCGSNT DKQTLTTPPRYPQKLLLPKP KVALVKLPVMQFSVMPVFVP TADSSAQPVVLGVDQGSATG AVHLMPLSVGTLILGLDSEA C |
| Tissue Specificity | Ubiquitously expressed in normal tissues and cancer cell lines with highest levels in placenta and skeletal muscle. |
| Function | Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription. |
| Protein Name | Atm InteractorAtm/Atr-Substrate Chk2-Interacting Zinc Finger ProteinAscizZinc Finger Protein 822 |
| Cellular Localisation | NucleusNuclearIn Discrete Foci During G1 Phase |
| Alternative Antibody Names | Anti-Atm Interactor antibodyAnti-Atm/Atr-Substrate Chk2-Interacting Zinc Finger Protein antibodyAnti-Asciz antibodyAnti-Zinc Finger Protein 822 antibodyAnti-ATMIN antibodyAnti-KIAA0431 antibodyAnti-ZNF822 antibody |
Information sourced from Uniprot.org