| Function | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization. |
| Protein Name | Bifunctional Purine Biosynthesis Protein AticAicar Transformylase/Inosine Monophosphate CyclohydrolaseAtic Cleaved Into - Bifunctional Purine Biosynthesis Protein Atic - N-Terminally Processed Includes - Phosphoribosylaminoimidazolecarboxamide Formyltransferase5-Aminoimidazole-4-Carboxamide Ribonucleotide FormyltransferaseAicar FormyltransferaseAicar Transformylase - Inosine 5'-Monophosphate CyclohydrolaseImp CyclohydrolaseImp SynthaseInosinicase |
| Database Links | Reactome: R-HSA-73817Reactome: R-HSA-9725370 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Bifunctional Purine Biosynthesis Protein Atic antibodyAnti-Aicar Transformylase/Inosine Monophosphate Cyclohydrolase antibodyAnti-Atic Cleaved Into - Bifunctional Purine Biosynthesis Protein Atic - N-Terminally Processed Includes - Phosphoribosylaminoimidazolecarboxamide Formyltransferase antibodyAnti-5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase antibodyAnti-Aicar Formyltransferase antibodyAnti-Aicar Transformylase - Inosine 5'-Monophosphate Cyclohydrolase antibodyAnti-Imp Cyclohydrolase antibodyAnti-Imp Synthase antibodyAnti-Inosinicase antibodyAnti-ATIC antibodyAnti-PURH antibodyAnti-OK antibodyAnti-SW-cl.86 antibody |
Information sourced from Uniprot.org
