| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ATF7IP (525-725) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ATF7IP |
| Gene ID: |
55729 |
| Uniprot ID: |
MCAF1_HUMAN |
| Immunogen Region: |
525-725 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 525-725 of human ATF7IP (NP_060649.3). |
| Immunogen Sequence: |
NEKDNKPEEEEQVIHEDDER PSEKNEFSRRKRSKSEDMDN VQSKRRRYMEEEYEAEFQVK ITAKGDINQKLQKVIQWLLE EKLCALQCAVFDKTLAELKT RVEKIECNKRHKTVLTELQA KIARLTKRFEAAKEDLKKRH EHPPNPPVSPGKTVNDVNSN NNMSYRNAGTVRQMLESKRN VSESAPPSFQTPVNTVSSTN L |
| Tissue Specificity | Detected at low levels in breast, lung and stomach.highly up-regulated in the corresponding cancerous tissues (at protein level). |
| Function | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells. |
| Protein Name | Activating Transcription Factor 7-Interacting Protein 1Atf-Interacting ProteinAtf-IpAtf7-Interacting ProteinAtfa-Associated ModulatorHamMbd1-Containing Chromatin-Associated Factor 1P621 |
| Database Links | Reactome: R-HSA-3214841 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Activating Transcription Factor 7-Interacting Protein 1 antibodyAnti-Atf-Interacting Protein antibodyAnti-Atf-Ip antibodyAnti-Atf7-Interacting Protein antibodyAnti-Atfa-Associated Modulator antibodyAnti-Ham antibodyAnti-Mbd1-Containing Chromatin-Associated Factor 1 antibodyAnti-P621 antibodyAnti-ATF7IP antibodyAnti-MCAF antibodyAnti-MCAF1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
