Tissue Specificity | Detected at low levels in breast, lung and stomach.highly up-regulated in the corresponding cancerous tissues (at protein level). |
Function | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells. |
Protein Name | Activating Transcription Factor 7-Interacting Protein 1Atf-Interacting ProteinAtf-IpAtf7-Interacting ProteinAtfa-Associated ModulatorHamMbd1-Containing Chromatin-Associated Factor 1P621 |
Database Links | Reactome: R-HSA-3214841Reactome: R-HSA-9843940Reactome: R-HSA-9843970 |
Cellular Localisation | Nucleus |
Alternative Antibody Names | Anti-Activating Transcription Factor 7-Interacting Protein 1 antibodyAnti-Atf-Interacting Protein antibodyAnti-Atf-Ip antibodyAnti-Atf7-Interacting Protein antibodyAnti-Atfa-Associated Modulator antibodyAnti-Ham antibodyAnti-Mbd1-Containing Chromatin-Associated Factor 1 antibodyAnti-P621 antibodyAnti-ATF7IP antibodyAnti-MCAF antibodyAnti-MCAF1 antibody |
Information sourced from Uniprot.org