Anti-ATF1 antibody [R03-2E3] (STJA0036140)

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STJA0036140
£133.50 - £281.50
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Host: Rabbit
Applications: WB/ICC/IF/IP
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal anti-ATF1 for use in WB, ICC, IF and IP in Human samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : R03-2E3
Conjugation: Unconjugated
Isotype: IgG
Formulation: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification: Affinity Chromatography
Dilution Range: WB 1:500-1:1000
IF 1:50-1:200
IP 1:50
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: ATF1
Gene ID: 466
Uniprot ID: ATF1_HUMAN
Immunogen: A synthesized peptide derived from human ATF1
Post Translational Modifications Phosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.
Function This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGTACAG-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
Protein Name Cyclic Amp-Dependent Transcription Factor Atf-1
Camp-Dependent Transcription Factor Atf-1
Activating Transcription Factor 1
Protein Treb36
Database Links Reactome: R-HSA-199920
Reactome: R-HSA-9031628
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Cyclic Amp-Dependent Transcription Factor Atf-1 antibody
Anti-Camp-Dependent Transcription Factor Atf-1 antibody
Anti-Activating Transcription Factor 1 antibody
Anti-Protein Treb36 antibody
Anti-ATF1 antibody

Information sourced from Uniprot.org

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