| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ATAD3B |
| Gene ID: | 83858 |
| Uniprot ID: | ATD3B_HUMAN |
| Immunogen Region: | 1-240 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human ATAD3B (NP_114127.3). |
| Immunogen Sequence: | MSWLFGVNKGPKGEGAGPPP PLPPAQPGAEGGGDRGLGDR PAPKDKWSNFDPTGLERAAK AARELEHSRYAKEALNLAQM QEQTLQLEQQSKLKEYEAAV EQLKSEQIRAQAEERRKTLS EETRQHQARAQYQDKLARQR YEDQLKQQQLLNEENLRKQE ESVQKQEAMRRATVEREMEL RHKNEMLRVETEARARAKAE RENADIIREQIRLKASEHRQ TVLESIRTAGTLFGEGFRA |
| Tissue Specificity | Tends to be down-regulated in differentiated cells and re-expressed in pluripotent stem cells or cancer cells (at protein level). |
| Function | May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. May act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes. |
| Protein Name | Atpase Family Aaa Domain-Containing Protein 3bAaa-Tob3 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinHas Been Found To Co-Purify With NucleoidsSince It Does Not Face The Mitochondrial MatrixThe Association With Nucleoids Could Be Mediated By Atad3a |
| Alternative Antibody Names | Anti-Atpase Family Aaa Domain-Containing Protein 3b antibodyAnti-Aaa-Tob3 antibodyAnti-ATAD3B antibodyAnti-KIAA1273 antibodyAnti-TOB3 antibody |
Information sourced from Uniprot.org