| Function | Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria. Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane. Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane.these activities are ATPase-dependent. |
| Protein Name | Outer Mitochondrial Transmembrane Helix TranslocaseAtpase Family Aaa Domain-Containing Protein 1Hatad1Thorase |
| Database Links | Reactome: R-HSA-9603798 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Membrane ProteinPeroxisome MembranePostsynaptic Cell Membrane |
| Alternative Antibody Names | Anti-Outer Mitochondrial Transmembrane Helix Translocase antibodyAnti-Atpase Family Aaa Domain-Containing Protein 1 antibodyAnti-Hatad1 antibodyAnti-Thorase antibodyAnti-ATAD1 antibodyAnti-FNP001 antibody |
Information sourced from Uniprot.org
