| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ASNA1 (1-348) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GET3 |
| Gene ID: |
439 |
| Uniprot ID: |
GET3_HUMAN |
| Immunogen Region: |
1-348 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-348 of human ASNA1 (NP_004308.2). |
| Immunogen Sequence: |
MAAGVAGWGVEAEEFEDAPD VEPLEPTLSNIIEQRSLKWI FVGGKGGVGKTTCSCSLAVQ LSKGRESVLIISTDPAHNIS DAFDQKFSKVPTKVKGYDNL FAMEIDPSLGVAELPDEFFE EDNMLSMGKKMMQEAMSAFP GIDEAMSYAEVMRLVKGMNF SVVVFDTAPTGHTLRLLNFP TIVERGLGRLMQIKNQISPF ISQMCNMLGLGDMNADQLAS KLEETLPVIRSVSEQFKDP |
| Tissue Specificity | Expressed in the epithelial cells of the liver, kidney, and stomach wall, in the adrenal medulla, in the islet cells of the pancreas, in the red pulp of the spleen, and in cardiac and skeletal muscle. |
| Function | ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling. |
| Protein Name | Atpase Get3Arsenical Pump-Driving AtpaseArsenite-Stimulated AtpaseGuided Entry Of Tail-Anchored Proteins Factor 3 - AtpaseTransmembrane Domain Recognition Complex 40 Kda Atpase SubunitHarsa-IHasna-I |
| Database Links | Reactome: R-HSA-9609523 |
| Cellular Localisation | CytoplasmEndoplasmic ReticulumNucleusNucleolus |
| Alternative Antibody Names | Anti-Atpase Get3 antibodyAnti-Arsenical Pump-Driving Atpase antibodyAnti-Arsenite-Stimulated Atpase antibodyAnti-Guided Entry Of Tail-Anchored Proteins Factor 3 - Atpase antibodyAnti-Transmembrane Domain Recognition Complex 40 Kda Atpase Subunit antibodyAnti-Harsa-I antibodyAnti-Hasna-I antibodyAnti-GET3 antibodyAnti-ARSA antibodyAnti-ASNA1 antibodyAnti-TRC40 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
