| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ASMT |
| Gene ID: | 438 |
| Uniprot ID: | ASMT_HUMAN |
| Immunogen Region: | 1-298 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-298 of human ASMT (NP_001164510.1). |
| Immunogen Sequence: | MGSSEDQAYRLLNDYANGFM VSQVLFAACELGVFDLLAEA PGPLDVAAVAAGVRASAHGT ELLLDICVSLKLLKVETRGG KAFYRNTELSSDYLTTVSPT SQCSMLKYMGRTSYRCWGHL ADAVREGRNQYLETFGVPAE ELFTAIYRSEGERLQFMQAL QEVWSVNGRSVLTAFDLSVF PLMCDLGGDFFKDPLPEADL YILARVLHDWADGKCSHLLE RIYHTCKPGGGILVIESLL |
| Tissue Specificity | Expressed in the pineal gland (at protein level). In the retina, very low expression is found at the mRNA level, and not at the protein level. |
| Function | Isoform 1: Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2: Does not show Acetylserotonin O-methyltransferase activity. Isoform 3: Does not show Acetylserotonin O-methyltransferase activity. |
| Protein Name | Acetylserotonin O-MethyltransferaseHydroxyindole O-MethyltransferaseHiomt |
| Database Links | Reactome: R-HSA-209931 |
| Alternative Antibody Names | Anti-Acetylserotonin O-Methyltransferase antibodyAnti-Hydroxyindole O-Methyltransferase antibodyAnti-Hiomt antibodyAnti-ASMT antibody |
Information sourced from Uniprot.org