Anti-ASIC1 antibody (70-360 aa) (STJ11105986)

SKU:
STJ11105986
£112.50 - £524.50
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Gene Symbol: ASIC1
Gene ID: 41
Uniprot ID: ASIC1_HUMAN
Immunogen Region: 70-360 aa
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 70-360 of human ASIC1 (P78348).
Immunogen Sequence: HYHHVTKLDEVAASQLTFPA VTLCNLNEFRFSQVSKNDLY HAGELLALLNNRYEIPDTQM ADEKQLEILQDKANFRSFKP KPFNMREFYDRAGHDIRDML LSCHFRGEVCSAEDFKVVFT RYGKCYTFNSGRDGRPRLKT MKGGTGNGLEIMLDIQQDEY LPVWGETDETSFEAGIKVQI HSQDEPPFIDQLGFGVAPGF QTFVACQEQRLIYLPPPWGT CKAVTMDSDLDFFDSYSIT
Tissue Specificity Expressed in most or all neurons.
Post Translational Modifications Phosphorylation by PKA regulates interaction with PRKCABP and subcellular location. Phosphorylation by PKC may regulate the channel.
Function Isoform 2 and isoform 3 function as proton-gated sodium channels.they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. Isoform 1 does not display proton-gated cation channel activity.
Protein Name Acid-Sensing Ion Channel 1
Asic1
Amiloride-Sensitive Cation Channel 2 - Neuronal
Brain Sodium Channel 2
Bnac2
Database Links Reactome: R-HSA-2672351
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Localizes In Synaptosomes At Dendritic Synapses Of Neurons
Colocalizes With Dlg4
Alternative Antibody Names Anti-Acid-Sensing Ion Channel 1 antibody
Anti-Asic1 antibody
Anti-Amiloride-Sensitive Cation Channel 2 - Neuronal antibody
Anti-Brain Sodium Channel 2 antibody
Anti-Bnac2 antibody
Anti-ASIC1 antibody
Anti-ACCN2 antibody
Anti-BNAC2 antibody

Information sourced from Uniprot.org