• Immunofluorescence analysis of paraffin-embedded Mouse liver tissue using ASGR2 Rabbit polyclonal antibody (STJ28203) at a dilution of 1:100 (40x lens). Secondary antibody:Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining. Perform high pressure antigen retrieval with 0. 01 M citrate buffer (pH 6. 0) prior to IF staining.
  • Immunofluorescence analysis of paraffin-embedded Human liver tissue using ASGR2 Rabbit polyclonal antibody (STJ28203) at a dilution of 1:100 (40x lens). Secondary antibody:Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining. Perform high pressure antigen retrieval with 0. 01 M citrate buffer (pH 6. 0) prior to IF staining.
  • Immunofluorescence analysis of paraffin-embedded Human liver cancer tissue using ASGR2 Rabbit polyclonal antibody (STJ28203) at a dilution of 1:100 (40x lens). Secondary antibody:Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining. Perform high pressure antigen retrieval with 0. 01 M citrate buffer (pH 6. 0) prior to IF staining.
  • Western blot analysis of lysates from HepG2 cells, using ASGR2 Rabbit polyclonal antibody (STJ28203) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-ASGR2 antibody (58-287) (STJ28203)

SKU:
STJ28203

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ASGR2 (58-287) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ASGR2
Gene ID: 433
Uniprot ID: ASGR2_HUMAN
Immunogen Region: 58-287
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 58-287 of human ASGR2 (NP_550435.1).
Immunogen Sequence: TGSQSAQLQAELRSLKEAFS NFSSSTLTEVQAISTHGGSV GDKITSLGAKLEKQQQDLKA DHDALLFHLKHFPVDLRFVA CQMELLHSNGSQRTCCPVNW VEHQGSCYWFSHSGKAWAEA EKYCQLENAHLVVINSWEEQ KFIVQHTNPFNTWIGLTDSD GSWKWVDGTDYRHNYKNWAV TQPDNWHGHELGGSEDCVEV QPDGRWNDDFCLQVYRWVCE KRRNATGEVA
Tissue Specificity Expressed exclusively in hepatic parenchymal cells.
Function Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Protein Name Asialoglycoprotein Receptor 2
Asgp-R 2
Asgpr 2
C-Type Lectin Domain Family 4 Member H2
Hepatic Lectin H2
Hl-2
Database Links Reactome: R-HSA-446203
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Alternative Antibody Names Anti-Asialoglycoprotein Receptor 2 antibody
Anti-Asgp-R 2 antibody
Anti-Asgpr 2 antibody
Anti-C-Type Lectin Domain Family 4 Member H2 antibody
Anti-Hepatic Lectin H2 antibody
Anti-Hl-2 antibody
Anti-ASGR2 antibody
Anti-CLEC4H2 antibody

Information sourced from Uniprot.org

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