| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ASGR2 |
| Gene ID: | 433 |
| Uniprot ID: | ASGR2_HUMAN |
| Immunogen Region: | 58-287 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 58-287 of human ASGR2 (NP_550435.1). |
| Immunogen Sequence: | CFSLLALSFNILLLVVICVT GSQSEGHGGAQLQAELRSLK EAFSNFSSSTLTEVQAISTH GGSVGDKITSLGAKLEKQQQ DLKADHDALLFHLKHFPVDL RFVACQMELLHSNGSQRTCC PVNWVEHQGSCYWFSHSGKA WAEAEKYCQLENAHLVVINS WEEQKFIVQHTNPFNTWIGL TDSDGSWKWVDGTDYRHNYK NWAVTQPDNWHGHELGGSED CVEVQPDGRWNDDFCLQVY |
| Tissue Specificity | Expressed exclusively in hepatic parenchymal cells. |
| Function | Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. |
| Protein Name | Asialoglycoprotein Receptor 2Asgp-R 2Asgpr 2C-Type Lectin Domain Family 4 Member H2Hepatic Lectin H2Hl-2 |
| Database Links | Reactome: R-HSA-446203 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Asialoglycoprotein Receptor 2 antibodyAnti-Asgp-R 2 antibodyAnti-Asgpr 2 antibodyAnti-C-Type Lectin Domain Family 4 Member H2 antibodyAnti-Hepatic Lectin H2 antibodyAnti-Hl-2 antibodyAnti-ASGR2 antibodyAnti-CLEC4H2 antibody |
Information sourced from Uniprot.org
