| Function | ATPase involved both in DNA repair and rescue of stalled ribosomes. 3'-5' DNA helicase involved in repair of alkylated DNA: promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Drives the splitting of stalled ribosomes that are ubiquitinated in a ZNF598-dependent manner, as part of the ribosome quality control trigger (RQT) complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. |
| Protein Name | Activating Signal Cointegrator 1 Complex Subunit 3Asc-1 Complex Subunit P200Asc1p200Helicase - Atp Binding 1Trip4 Complex Subunit P200 |
| Database Links | Reactome: R-HSA-112126 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasmCytosolColocalizes With Alkbh3 And Ascc2 In Nuclear Foci When Cells Have Been Exposed To Alkylating Agents That Cause Dna Damage |
| Alternative Antibody Names | Anti-Activating Signal Cointegrator 1 Complex Subunit 3 antibodyAnti-Asc-1 Complex Subunit P200 antibodyAnti-Asc1p200 antibodyAnti-Helicase - Atp Binding 1 antibodyAnti-Trip4 Complex Subunit P200 antibodyAnti-ASCC3 antibodyAnti-HELIC1 antibodyAnti-RQT2 antibody |
Information sourced from Uniprot.org
