| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARSB |
| Gene ID: | 411 |
| Uniprot ID: | ARSB_HUMAN |
| Immunogen Region: | 404-533 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 404-533 of human ARSB (NP_000037.2). |
| Immunogen Sequence: | PCPRNSMAPAKDDSSLPEYS AFNTSVHAAIRHGNWKLLTG YPGCGYWFPPPSQYNVSEIP SSDPPTKTLWLFDIDRDPEE RHDLSREYPHIVTKLLSRLQ FYHKHSVPVYFPAQDPRCDP KATGVWGPWM |
| Post Translational Modifications | The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. This post-translational modification is severely defective in multiple sulfatase deficiency (MSD). |
| Function | Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. |
| Protein Name | Arylsulfatase BAsbN-Acetylgalactosamine-4-SulfataseG4s |
| Database Links | Reactome: R-HSA-1663150Reactome: R-HSA-2024101Reactome: R-HSA-2206285Reactome: R-HSA-6798695Reactome: R-HSA-9840310 |
| Cellular Localisation | LysosomeCell Surface |
| Alternative Antibody Names | Anti-Arylsulfatase B antibodyAnti-Asb antibodyAnti-N-Acetylgalactosamine-4-Sulfatase antibodyAnti-G4s antibodyAnti-ARSB antibody |
Information sourced from Uniprot.org
