| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-ADP-ribosylation factor-like protein 6-interacting protein 1 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARL6IP1 |
| Gene ID: | 23204 |
| Uniprot ID: | AR6P1_HUMAN |
| Specificity: | This antibody detects endogenous levels of ARMER at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human ARMER |
| Function | Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport. Plays a role in the formation and stabilization of endoplasmic reticulum tubules. Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself. May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. |
| Protein Name | Adp-Ribosylation Factor-Like Protein 6-Interacting Protein 1 Arl-6-Interacting Protein 1 Aip-1 Apoptotic Regulator In The Membrane Of The Endoplasmic Reticulum |
| Cellular Localisation | Endomembrane System Multi-Pass Membrane Protein Endoplasmic Reticulum Membrane Endoplasmic Reticulum Predominantly Localized To Intracytoplasmic Membranes Preferentially Localizes At The Er Tubules And The Edge Of The Er Sheets Both Of Which Are Characterized By A High Membrane Curvature |
| Alternative Antibody Names | Anti-Adp-Ribosylation Factor-Like Protein 6-Interacting Protein 1 antibody Anti-Arl-6-Interacting Protein 1 antibody Anti-Aip-1 antibody Anti-Apoptotic Regulator In The Membrane Of The Endoplasmic Reticulum antibody Anti-ARL6IP1 antibody Anti-ARL6IP antibody Anti-ARMER antibody Anti-KIAA0069 antibody |
Information sourced from Uniprot.org