| Function | Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport. Plays a role in the formation and stabilization of endoplasmic reticulum tubules. Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself. May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. |
| Protein Name | Adp-Ribosylation Factor-Like Protein 6-Interacting Protein 1Arl-6-Interacting Protein 1Aip-1Apoptotic Regulator In The Membrane Of The Endoplasmic Reticulum |
| Cellular Localisation | Endomembrane SystemMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneEndoplasmic ReticulumPredominantly Localized To Intracytoplasmic MembranesPreferentially Localizes At The Er Tubules And The Edge Of The Er SheetsBoth Of Which Are Characterized By A High Membrane Curvature |
| Alternative Antibody Names | Anti-Adp-Ribosylation Factor-Like Protein 6-Interacting Protein 1 antibodyAnti-Arl-6-Interacting Protein 1 antibodyAnti-Aip-1 antibodyAnti-Apoptotic Regulator In The Membrane Of The Endoplasmic Reticulum antibodyAnti-ARL6IP1 antibodyAnti-ARL6IP antibodyAnti-ARMER antibodyAnti-KIAA0069 antibody |
Information sourced from Uniprot.org
